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ea0008oc23 | Young Endocrinologist Session | SFE2004

Adrenal and circulating agouti related protein (AgRP) is upregulated in Cushing's syndrome suggesting a novel inhibitory paracrine role in the human adrenal gland

Dhillo WS , Castle L , Gardiner JV , Bewick GA , Smith KL , Meeran K , Todd JF , Ghatei MA , Bloom SR

Alpha melanocyte stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 receptor (MC3-R) and MC4-R and stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing's syndrome have elevated levels of serum alpha-MSH. Agouti related protein (AgRP) is an endogenous antagonist at the MC3-R and MC4-R and is expressed in the rat adrenal cortex. AgRP antagonises alpha-MSH-induced corticosterone release from rat and bovine adrenal cells. This ...

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Endocrine Abstracts

Adrenal and circulating agouti related protein (AgRP) is upregulated in Cushing's syndrome suggesting a novel inhibitory paracrine role in the human adrenal gland

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